Journal article
E. Lampe, April Park, Mark Seewald, Gary Freedman, Julia Boyle, Michael Perlis, A. Muench
Sleep, 2024
Sleep, 2024
Semantic Scholar
DOI
Cite
Cite
APA
Click to copy
Lampe, E., Park, A., Seewald, M., Freedman, G., Boyle, J., Perlis, M., & Muench, A. (2024). 0904 The Prevalence of Insomnia and Fatigue in Cancer Patients Pre-Post Radiation Treatment. Sleep.
Chicago/Turabian
Click to copy
Lampe, E., April Park, Mark Seewald, Gary Freedman, Julia Boyle, Michael Perlis, and A. Muench. “0904 The Prevalence of Insomnia and Fatigue in Cancer Patients Pre-Post Radiation Treatment.” Sleep (2024).
MLA
Click to copy
Lampe, E., et al. “0904 The Prevalence of Insomnia and Fatigue in Cancer Patients Pre-Post Radiation Treatment.” Sleep, 2024.
BibTeX Click to copy
@article{e2024a,
title = {0904 The Prevalence of Insomnia and Fatigue in Cancer Patients Pre-Post Radiation Treatment},
year = {2024},
journal = {Sleep},
author = {Lampe, E. and Park, April and Seewald, Mark and Freedman, Gary and Boyle, Julia and Perlis, Michael and Muench, A.}
}
Abstract
Insomnia and Cancer-related fatigue (CRF) are highly prevalent during acute illness and survivorship, with almost 100% of cancer patients experiencing at least one of these at some point during treatment. Concerningly, insomnia and CRF have long-term effects on quality of life, daytime function, and are associated with medical and psychiatric morbidity. No studies to date have assessed concurrent change in CRF and insomnia with radiation therapy. Thus, the present analysis aimed to characterize insomnia & CRF prevalence and severity pre- and post-radiation.
Insomnia and fatigue were assessed pre- and post-radiation among 32 adults diagnosed with cancer (Mage=58.22 years, SDage=10.54, 46.9% female, 62.5% White). Subjects were asked to complete the Insomnia Severity Index, Functional Assessment of Chronic Illness Therapy – Fatigue Scale (FACIT-F), Brief Fatigue Inventory (BFI) and PROMIS-SF Fatigue 7A at each timepoint. Descriptive statistics are used characterize the severity of insomnia and CRF at each timepoint and exploratory t-tests examined whether sex was associated with change in insomnia and fatigue severity from pre- to post-radiation.
The mean ISI total score was 8.25 (SD=5.01) pre-radiation, and 8.50 (SD=3.46) post-radiation. The mean FACIT-F total score was 40.34 (SD=9.01) pre-radiation and 34.67 (SD=8.69) post-radiation. There was one (3.12%) case of new-onset clinical insomnia and five (15.63%) cases of new-onset clinical fatigue from pre- to post-radiation. Females reported greater increases in fatigue from pre- to post-radiation compared to males (t(31)=-4.612, p < 0.001, d=-1.44).
Insomnia and fatigue are highly prevalent in patients diagnosed with cancer at both pre- and post-radiation. Overall, insomnia stayed relatively stable while fatigue increased over treatment. This suggests that separate mechanisms may drive cancer-related fatigue and insomnia. Fatigue increased over treatment for both men and women, however this effect was stronger for women. A better understanding of mechanisms of insomnia and CRF may allow for earlier detection of insomnia and CRF as well as the use of targeted interventions for individuals struggling with CRF and/or insomnia during cancer treatment and recovery, especially among women.
University of Pennsylvania, Radiation Oncology, Chair's Summer Research Grant