Journal article
A. Muench, E. Lampe, J. Boyle, Mark Seewald, Michelle G. Thompson, M. Perlis, Ivan Vargas
Journal of Clinical Medicine, 2023
Journal of Clinical Medicine, 2023
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DOI
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APA
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Muench, A., Lampe, E., Boyle, J., Seewald, M., Thompson, M. G., Perlis, M., & Vargas, I. (2023). The Assessment of Post-COVID Fatigue and Its Relationship to the Severity and Duration of Acute COVID Illness. Journal of Clinical Medicine.
Chicago/Turabian
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Muench, A., E. Lampe, J. Boyle, Mark Seewald, Michelle G. Thompson, M. Perlis, and Ivan Vargas. “The Assessment of Post-COVID Fatigue and Its Relationship to the Severity and Duration of Acute COVID Illness.” Journal of Clinical Medicine (2023).
MLA
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Muench, A., et al. “The Assessment of Post-COVID Fatigue and Its Relationship to the Severity and Duration of Acute COVID Illness.” Journal of Clinical Medicine, 2023.
BibTeX Click to copy
@article{a2023a,
title = {The Assessment of Post-COVID Fatigue and Its Relationship to the Severity and Duration of Acute COVID Illness},
year = {2023},
journal = {Journal of Clinical Medicine},
author = {Muench, A. and Lampe, E. and Boyle, J. and Seewald, Mark and Thompson, Michelle G. and Perlis, M. and Vargas, Ivan}
}
Abstract
Emerging data suggests that COVID-19 is associated with fatigue well beyond the acute illness period. The present analysis aimed to: (1) characterize the prevalence and incidence of high fatigue at baseline and follow-up; (2) examine the impact of COVID-19 diagnosis on fatigue level following acute illness; and (3) examine the impact of acute COVID-19 symptom severity and duration on fatigue at follow-up. Subjects (n = 1417; 81.0% female; 83.3% White; X¯age = 43.6 years) completed the PROMIS-Fatigue during the initial wave of the pandemic at baseline (April–June 2020) and 9-month follow-up (January–March 2021). A generalized linear model (binomial distribution) was used to examine whether COVID-19 positivity, severity, and duration were associated with higher fatigue level at follow-up. Prevalence of high fatigue at baseline was 21.88% and 22.16% at follow-up, with 8.12% new cases at follow-up. Testing positive for COVID-19 was significantly associated with higher fatigue at follow-up. COVID-19 symptom duration and severity were significantly associated with increased fatigue at follow-up. COVID-19 symptom duration and severity during acute illness may precipitate longer-term fatigue, which could have implications for treatment planning and future research. Future studies should further evaluate the relationship between symptom severity, duration, and fatigue.